Augmentin

Augmentin®

(amoxicillin/clavulanate potassium) Tablets

Augmentin description

Augmentin is a penicillin antibiotic.

Augmentin contains a combination of amoxicillin and clavulanate potassium. Amoxicillin is an antibiotic in a group of drugs called penicillins. Amoxicillin fights bacteria in the body.

Clavulanate potassium is a form of clavulanic acid. It is used to overcome resistance in bacteria that secrete beta-lactamase, thereby counteracting possible bacterial resistance to the amoxicillin.

Augmentin used for

Augmentin is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.

Augmentin XR

AUGMENTIN XR is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin (present as amoxicillin trihydrate and amoxicillin sodium) and the β-lactamase inhibitor clavulanate potassium (the potassium salt of clavulanic acid).

Augmentin dosages

Since both the Augmentin 250 mg and 500 mg tablets contain the same amount of clavulanic acid (125 mg, as the potassium salt), 2 Augmentin 250 mg tablets are not equivalent to 1 Augmentin 500 mg tablet. Therefore, 2 Augmentin 250 mg tablets should not be substituted for 1 Augmentin 500 mg tablet.

Dosage: Adults

The usual adult dose is 1 Augmentin 500 mg tablet every 12 hours or 1 Augmentin 250 mg tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be 1 Augmentin 875 mg tablet every 12 hours or 1 Augmentin 500 mg tablet every 8 hours.

Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Severely impaired patients with a glomerular filtration rate of <30 mL/ minute should not receive the 875 mg tablet.

Patients with a glomerular filtration rate of 10 to 30 mL/ minute should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection. Patients with a less than 10 mL/ minute glomerular filtration rate should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection.

Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis. Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals.

Pediatric Patients:

Pediatric patients weighing 40 kg or more should be dosed according to the adult recommendations. Due to the different amoxicillin to clavulanic acid ratios in the Augmentin 250 mg tablet (250/ 125) versus the Augmentin 250 mg chewable tablet (250/ 62.5), the Augmentin 250 mg tablet should not be used until the pediatric patient weighs at least 40 kg or more.

Augmentin  how supplied

AUGMENTIN 250 MG TABLETS

Each white oval filmcoated tablet, debossed with AUGMENTIN on 1 side and 250/ 125 on the other side, contains 250 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as the potassium salt. NDC 0029-6075-27..... bottles of 30 NDC 0029-6075-31.....Unit Dose (10x10) 100 tablets

AUGMENTIN 500 MG TABLETS

Each white oval filmcoated tablet, debossed with AUGMENTIN on 1 side and 500/ 125 on the other side, contains 500 mg amoxicillin as the
trihydrate and 125 mg clavulanic acid as the potassium salt. NDC 0029-6080-12......bottles of 20 NDC 0029-6080-31........... Unit Dose (10x10) 100 tablets

AUGMENTIN 875 MG TABLETS

Each scored white capsule-shaped tablet, debossed with AUGMENTIN 875 on 1 side and scored on the other side, contains 875 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as the potassium salt. NDC 0029-6086-12...... bottles of 20 NDC 0029-6086-21........ Unit Dose (10x10) 100 tablets
AUGMENTIN is also supplied as: AUGMENTIN 125 MG/ 5 ML (125 mg amoxicillin/ 31.25 mg clavulanic acid) FOR ORAL SUSPENSION

Augmentin Side Effects

As with any medicine, side effects are possible with Augmentin® however, not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
Augmentin has been studied thoroughly in clinical trials, in which it was compared to its two components (amoxicillin and clavulanate potassium) used individually. Because these studies did not compare Augmentin to a placebo (a solution with no active ingredient), it is difficult to tell whether side effects were actually caused by the medications, the medical condition, or other problems.

In these studies, the most common side effects of Augmentin included:

• Nausea -- up to 3 percent
• Vomiting -- up to 1 percent.
• Diarrhea or loose stools -- in up to 9 percent of people

Some side effects with Augmentin, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:

• Severe diarrhea or diarrhea that lasts longer than two or three days
• Signs of liver damage, such as:

1. Yellow eyes or skin (jaundice)
2. Upper-right abdominal pain
3. Dark urine

• A vaginal yeast infection or thrush (a yeast infection of the mouth)
• Signs of an allergic reaction, including:

1. Unexplained rash
2. Hives
3. Itching
4. Unexplained swelling
5. Wheezing
6. Difficulty breathing or swallowing.